In general, most sponsors must be informed of any changes that effect the scope of the project (even if there is no associated budget revision) of the research to be performed as described in the proposal and as accepted during the award negotiations at the time of an award.

Indications of significant project change include:

  1. A significant change (decrease) in the percentage effort devoted by the key project personnel to the project is considered as affecting the scope of the research.
  2. An absence/change of the Principal Investigator.
  3. Change in the approved use of animals or human subjects, or a change in the objective or emphasis of the study.
  4. Change of grantee institution.


See – Prior Approval Requirements